- Master Slave optical coherence tomography1 (MS-OCT) operates like a time domain OCT1, selecting signal from a selected depth while scanning the laser beam across the sample.
Master Slave is a spectral (Fourier) domain OCT method, hence benefits from the sensitivity and speed advantage of the spectral (Fourier) domain methods in comparison with time domain method1, 3-5.
- Master Slave method allows collection of signals from any number of depths, as required by the user, ie of any number of en-face OCT images, from any depths, separated by any distance from the neighboring en-face slices1, 3-5. MS-OCT does not require resampling of data, hence no linearization, no calibration necessary, no clock needed in the swept source OCT, no linearized spectrometer in spectrometer based OCT1, 3-5.
- MS-OCT is tolerant to dispersion7, so no need to optimize the quantity of glass in the interferometer. Since no data re-sampling is required, the sensitivity at large depths provided by the method proposed is slightly superior to that provided by the FFT based technique1, 3-5. The depth resolution does not depend on the way in which data are sampled, and reaches the theoretical expected limit1, 3-5.
- The Master Slave method is ideally suited to production of en-face OCT images from any tissue, including the eye, to satisfy the recent revival of interest in the en-face orientation7,8.
- The MS method is ideally suited for parallel computing algorithms on GPUs due to its parallel nature. Recently, we have demonstrated realtime production of MS based B-scan images of the human retina9 as well as a dual modality imaging system en-face SLO/OCT entirely based on MS method 10.
- A. Gh. Podoleanu and A. Bradu, “Master-slave interferometry for parallel spectral domain interferometry sensing and versatile 3D optical coherence tomography,” Opt. Express 21, 19324-19338 (2013).
- A. Gh. Podoleanu, “Principles of en-face optical coherence tomography: real time and post-processing en-face imaging in ophthalmology,” (in Clinical en-face OCT atlas, B. Lambruso, D. Huang, A. Romano, M. Rispoli, G. Coscas eds., J.P. Medical Ltd 2013), Chap. 1.
- A. Bradu and A. Gh. Podoleanu, “Calibration-free B-scan images produced by master/slave optical coherence tomography,” Opt. Lett. 39, 450-453 (2014).
- A. Bradu and A. Gh. Podoleanu, “Imaging the eye fundus with real-time en-face spectral domain optical coherence tomography,” Biomed. Opt. Express 5, 1233-1249 (2014).
- K. Kapinchev, F. Barnes, A. Bradu, A. Gh. Podoleanu, “Approaches to General Purpose GPU Acceleration of Digital Signal Processing in Optical Coherence Tomography Systems,” IEEE International Conference on Systems, Man, and Cybernetics (SMC), 2013, 2576-2580, (2013).
- A. Bradu, M. Maria, and A. Podoleanu, “Demonstration of tolerance to dispersion of master/slave interferometry,” Opt. Express 23, 14148-14161 (2015).
- First international congress of en-face OCT, Rome 2013.
- Second International Congress on “En-Face” OCT imaging New Developments in OCT, OCT Angiography, Rome, 2014.
- Adrian Bradu, Konstantin Kapinchev, Frederick Barnes, and Adrian Podoleanu, “On the possibility of producing true real-time retinal cross-sectional images using a graphics processing unit enhanced master-slave optical coherence tomography system,” J. Biomed. Opt., 20, 076008 (2015).
- Adrian Bradu, Konstantin Kapinchev, Frederick Barnes, and Adrian Podoleanu, “Master slave en-face OCT/SLO,” Biomed. Opt. Express 6, 3655-3669 (2015).
Applications of Master-Slave OCT
MS-OCT has been successfully applied to many different OCT-based applications, including multi-modal imaging and extended-functionality OCT systems. This technique has been featured on OCT News in August 2016.
A number of publications on the subject can be seen below:
- M. Bondu, M. J. Marques, P. M. Moselund, G. Lall, A. Bradu, A. Podoleanu, “Multispectral photoacoustic microscopy and optical coherence tomography using a single supercontinuum source“, Photoacoustics 9, pp. 21-30 (2018).
- S. Caujolle, R. Cernat, G. Silvestri, M. J. Marques, A. Bradu, T. Feuchter, G. Robinson, D. K. Griffin, A. Podoleanu, “Speckle variance OCT for depth resolved assessment of the viability of bovine embryos“, Biomed. Opt. Express 8(11), pp. 5139-5150 (2017).
- S. Rivet, M. J. Marques, A. Bradu, A. Podoleanu, “Passive optical module for polarization-sensitive optical coherence tomography systems“, Opt. Express 25(13), pp. 14533-14544 (2017).
- R. Cernat, A. Bradu, N. M. Israelsen, O. Bang, S. Rivet, P. A. Keane, D. G. Heath, R. Rajendram, A. Podoleanu, “Gabor fusion master slave optical coherence tomography“, Biomed. Opt. Express 8(2), pp. 813-827 (2017).
- C. Chin, A. Bradu, R. Lim, M. Khandwala, J. Schofield, L. Leick, A. Podoleanu, “Master/slave optical coherence tomography imaging of eyelid basal cell carcinoma“, Appl. Opt. 55(26), pp. 7378-7386 (2016).
- A. Bradu, S. Rivet, A. Podoleanu, “Master/slave interferometry–ideal tool for coherence revival swept source optical coherence tomography“, Biomed. Opt. Express 7(7), pp. 2453-2468 (2016).
- J. Wang, A. Bradu, G. Dobre, A. Podoleanu, “Full-field swept source master-slave optical coherence tomography“, IEEE Phot. Journal 7(4), pp. 1-14 (2015).