KAIROS researchers contribute to a groundbreaking study on SuFEx-functionalised quinones, featured as the cover article in Chemistry – An Asian Journal, advancing both synthetic chemistry and trypanocidal research.
A collaborative effort involving KAIROS researchers has culminated in the development of a novel ruthenium-catalyzed C−H alkenylation protocol to create 1,4-naphthoquinoidal/SuFEx hybrids. This modular approach enables direct access to ethenesulfonyl-fluorinated quinone structures with moderate to good yields. Mechanistic studies provided a deeper understanding of the reaction’s elementary steps, while biological evaluations identified potent trypanocidal prototypes effective against Trypanosoma cruzi, the causative agent of Chagas disease.
This research, co-authored by Cauê Souza and Felipe Fantuzzi, exemplifies the interdisciplinary potential of combining synthetic chemistry and medicinal applications. The findings, published in the August 2024 issue, mark a significant step forward in both the development of quinone-based frameworks and their applications in combating parasitic diseases.
For the full article, visit Chemistry – An Asian Journal.