Cellular Architecture and Dynamics Research Group

We use solution NMR in combination with X-Ray crystallography and other biophysical techniques to understand the structure, interactions, dynamics and function of membrane proteins.

We are particularly interested in studying proteins that are expressed in a soluble form but that, upon activation, can change their structure and insert in the membrane, where they have a completely different function.

We are also interested in NMR method development for the study of such complicated systems.

Current projects:

  • Investigations of structure, dynamics and inhibition of proteins of the CLIC family of chloride channels
  • Development of methodologies to study membrane protein-lipid specificity
  • Study of membrane interaction of different peptides involved in disease.

We are looking for enthusiastic researchers to join our group. For enquiries please email j.l.ortega-roldan@kent.ac.uk