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SoCoBio

Bioscience for an integrated understanding of health

The role of endometrial gland derived extracellular vesicles in mediating an optimal uterine environment Primary Supervisor

Dissecting Signalling Pathways with PROTAC Chemical Probes

Interrogating the b-catenin interactome for novel modulators of Wnt signaling

Control of Listeria monocytogenes in the fresh produce supply chain

Assembly and Dynamics of DNA Repair Complexes

Regulating RNA stability to increase protein production of cells under stress conditions

Modelling drug and ion transfer through trans-syncytial nanopores

Next generation mitochondrial inhibitors – a new approach to prevent fungal biofilm formation on medical implants

Exploiting rare human disease genomics to discover novel developmental control genes.

Bioactive natural products from the microbiome – an innovative approach to healthy ageing

Microbes and the ageing brain: do host-microbe interactions accelerate age-related cognitive decline?

How does a mild restriction in blood supply constrain hippocampal function?

Unveiling the role of ApoE in microglial development and function

A novel regulator of axon pathfinding in the brain: Regulation of axon-matrix interactions by the signalling protein alpha2-chimaerin

Harnessing bioactive nanoclay for tissue regeneration

Non-canonical interactions in the eukaryotic translation initiation factor machinery: novel partners of the m7G-cap binding protein, eIF4E

Analysing the functional significance of a primate-specific non-canonical glutamate receptor subunit.

Elucidating the molecular mechanism of Candida albicans environmental adaptation and its impact on the host-pathogen interaction

Unravelling Genome Packaging during Recombinant AAV (rAAV) Gene Therapy Viral Vector Production

Zebrafish model of ageing-related cognitive decline and visual impairment

The role of the nucleus accumbens in stimulus-controlled appetite and satiety

New regulators of cell division

Environmental and intra/interspecific approaches to nutrient security – Fruit for the UK’s food security

Friendly fire: understanding regulation of the genome editing enzyme APOBEC3A in cell growth and anti-viral responses (CASE project)

The influence of oxidative stress on protein structure and assembly in Alzheimer’s and other neurodegenerative diseases

Prediction of drug-induced renal injury using machine learning applied to in vitro and in silico parameters

Wiring up the nervous system: investigating the role of microtubules and motors in neuronal outgrowth

From atomic to in vivo: a characterization of ILF3 nucleic-acids interactions in the context of eukaryotic transcription regulation

Understanding the epigenetic regulation of fibroblast ageing

Eating and Sleeping: How neuronal SKN-1/Nrf regulates satiety using the worm C. elegans.

Inhibition of eukaryotic elongation factor 2 kinase (eEF2K). Synthesis of novel small molecule inhibitors for a potential cancer target

Safeguarding UK hop production from Verticillium nonalfalfae: Using genomics to develop race-specific diagnostics and generate Verticillium resistant hop through Host Induced Gene Silencing

The role of endometrial gland derived extracellular vesicles in mediating an optimal uterine environment

The roles of evolutionarily conserved microRNAs in feeding and nutrition - from flies to mammals

Investigations of the determinants of nerve agent potency to define novel routes to mitigate the effects of environmental toxins.

Development of selective CLIC1 inhibitors for the treatment of glioblastoma

Validating potassium channels from pathogenic fungi as new strategic antifungal targets

How does mis-activation of testis-specific genes disrupt mitotic cell division? (CASE project)

Resistance is futile: hijacking bacterial signal transduction pathways to increase antibiotic uptake.

Live long and prosper: probing the mechanism of a transporter family linked to lifespan extension, protection from diabetes and obesity, and cancer.

The effect of the microbiome and microbial bioactives on semen quality and reproductive health (CASE project)

Investigations of the determinants of nerve agent potency to define novel routes to mitigate the effects of environmental toxins (CASE project)

3D printing of innovative dual complex scaffolds for the repair of osteochondral defects

Nanodroplet emulsions for oxygen delivery in bone repair

Using phosphorothioate reactivity to analyse and control aptamers for protein binding

What are the sequence determinants of amyloid filament assembly and structural polymorphism?