his work uses computational approaches to analyze genetic variation and identify the functional effects that are associated with diseases including reproductive traits. Mark has developed methods for the analysis of genetic variation (VarMod – www.wasslab.org/varmod) prediction of protein function (ConFunc and CombFunc at http://www.sbg.bio.ic.ac.uk/combfunc) and for the prediction of small molecule binding sites in proteins (3DLigandSite –http://www.sbg.bio.ic.ac.uk/3dligandsite). Recent research has demonstrated the ability to use protein-protein docking tools to predict interactions between proteins. The work is highly collaborative with a number of genome wide association and sequencing studies and currently has a joint PhD studentship with Professor Darren Griffin to work on production and reproduction traits in farm animals.
