Myosin Motors are present in the nucleus and participate in genome organisation, transcription and DNA repair, but the role they play is unclear.
For the first time we combine classical biochemical and single molecule assays to provide a quantitative high resolution description of the activity of these nuclear myosins; providing a mechanistic insight into the activity of these proteins.
The lab specializes in application of fluorescence and mechanical measurements from whole cells to single molecules. We are a multidisciplinary lab drawing upon core techniques in Cell Biology, Biochemistry, Biophysics, Mechanobiology, Super Resolution imaging and Genomics.
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